SCHEMBL28064604

SCHEMBL28064604

Sc1ccnc(-c2cc(S)ccn2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 3/20 0.48
CCR5 P51681 3/20 0.48
CCR8 P51685 3/20 0.48
KDM4E B2RXH2 3/20 0.35
LMNA P02545 1/20 0.35
CYP1A2 P05177 1/20 0.35
POLB P06746 1/20 0.35
METAP1 P53582 1/20 0.35
BLM P54132 1/20 0.35
HIF1A Q16665 1/20 0.35
DOHH Q9BU89 1/20 0.35
P4HTM Q9NXG6 1/20 0.35
KDM5C P41229 3/20 0.33
KDM6B O15054 2/20 0.33
KDM4C Q9H3R0 2/20 0.33
KDM2A Q9Y2K7 2/20 0.33
KDM3A Q9Y4C1 2/20 0.33
KDM4A O75164 2/20 0.33
METAP2 P50579 1/20 0.33
ASIC3 Q9UHC3 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11198820 0.81 ASIC3 (0.59) KDM4ELMNACYP1A2ASIC3
SCHEMBL6363027 0.77
SCHEMBL22333823 0.75 CYP2A6 (0.64) CYP1A2
SCHEMBL11515982 0.74
SCHEMBL2646552 0.72
SCHEMBL2643798 0.72
SCHEMBL28049786 0.72
SCHEMBL11024887 0.72
SCHEMBL1145242 0.72
SCHEMBL25725277 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105503563-B One kind sulfur-bearing complex of iridium catalysis CO2The method of hydrogenating reduction 大连理工大学 2017-10-17 CN disclosed
CN-105503563-A Method for catalyzing CO2 hydrogenation reduction by using sulfur-containing iridium complex UNIV DALIAN TECH 2016-04-20 CN disclosed