Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1652841 | 0.81 | MEN1 (0.47) | MEN1CYP2D6CYP2C19KMT2ACHRNB2 | |
| SCHEMBL8611268 | 0.81 | CYP2D6 (0.47) | MEN1CYP2D6CYP2C19KMT2ACHRNB2 | |
| SCHEMBL27351589 | 0.78 | MEN1 (0.47) | MEN1CYP2D6CYP2C19KMT2ACHRNB2 | |
| SCHEMBL716893 | 0.76 | MKNK1 (0.48) | MEN1CYP2D6CYP2C19KMT2ACHRNB2 | |
| SCHEMBL6178200 | 0.76 | MKNK1 (0.48) | MEN1CYP2D6CYP2C19KMT2ACHRNB2 | |
| SCHEMBL23891896 | 0.74 | CYP2D6 (0.44) | MEN1CYP2D6CYP2C19KMT2ACHRNB2 | |
| SCHEMBL21806676 | 0.73 | CHRNB2 (0.44) | MEN1CYP2D6CYP2C19KMT2ACHRNB2 | |
| SCHEMBL16409303 | 0.73 | CYP4F2 (0.46) | MEN1CYP2D6CYP2C19KMT2ACHRNB2 | |
| SCHEMBL13499189 | 0.72 | HRH3 (0.55) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL3081329 | 0.72 | MEN1 (0.51) | MEN1CYP2D6CYP2C19KMT2ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579444-B | Piperidinylindole derivatives and their use as complement factor B inhibitors | 诺华股份有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-105579444-A | Piperidinylindole derivatives and their use as complement factor B inhibitors | NOVARTIS AG | 2016-05-11 | — | — | CN | disclosed |