Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.51 |
| ▸ | CCR5 | P51681 | 3/20 | 0.51 |
| ▸ | CCR8 | P51685 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | CBFB | Q13951 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12626761 | 0.82 | KDM4E (0.52) | CCR1CCR5CCR8NPC1ALDH1A1 | |
| SCHEMBL57525 | 0.82 | KDM4E (0.63) | CCR1CCR5CCR8NPC1ALDH1A1 | |
| SCHEMBL29484714 | 0.82 | KDM4E (0.63) | CCR1CCR5CCR8NPC1ALDH1A1 | |
| SCHEMBL31607260 | 0.82 | KDM4E (0.63) | CCR1CCR5CCR8NPC1ALDH1A1 | |
| SCHEMBL31473547 | 0.82 | KDM4E (0.63) | CCR1CCR5CCR8NPC1ALDH1A1 | |
| SCHEMBL28681737 | 0.81 | KDM4E (0.47) | CCR1CCR5CCR8NPC1ALDH1A1 | |
| SCHEMBL4242615 | 0.81 | KDM4E (0.54) | CCR1CCR5CCR8NPC1ALDH1A1 | |
| SCHEMBL31261515 | 0.81 | KDM4E (0.50) | CCR1CCR5CCR8NPC1ALDH1A1 | |
| SCHEMBL1817511 | 0.81 | KDM4E (0.50) | CCR1CCR5CCR8NPC1ALDH1A1 | |
| SCHEMBL20237398 | 0.80 | KDM4E (0.61) | CCR1CCR5CCR8NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102007125-B | fused heterocyclic derivatives and methods of use | AMGEN INC. (US) | 2016-05-25 | — | — | CN | disclosed |