Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluorouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.95 |
| ▸ | LMNA | P02545 | 2/20 | 0.95 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.95 |
| ▸ | TSHR | P16473 | 1/20 | 0.95 |
| ▸ | THPO | P40225 | 1/20 | 0.95 |
| ▸ | MTOR | P42345 | 1/20 | 0.95 |
| ▸ | HTT | P42858 | 1/20 | 0.95 |
| ▸ | HBB | P68871 | 1/20 | 0.95 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.95 |
| ▸ | DPYD | Q12882 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorouracil SCHEMBL249289 | 0.97 | MAPT (1.00) | MAPTALDH1A1LMNACYP19A1TSHR | |
| Fluorouracil SCHEMBL27850530 | 0.95 | MAPT (0.95) | MAPTALDH1A1LMNACYP19A1TSHR | |
| Fluorouracil SCHEMBL21527805 | 0.95 | MAPT (0.95) | MAPTALDH1A1LMNACYP19A1TSHR | |
| Fluorouracil SCHEMBL27648378 | 0.95 | MAPT (0.95) | MAPTALDH1A1LMNACYP19A1TSHR | |
| Fluorouracil SCHEMBL31441196 | 0.95 | MAPT (0.95) | MAPTALDH1A1LMNACYP19A1TSHR | |
| Fluorouracil SCHEMBL15284932 | 0.95 | MAPT (0.95) | MAPTALDH1A1LMNACYP19A1TSHR | |
| Fluorouracil SCHEMBL30439198 | 0.95 | MAPT (0.95) | MAPTALDH1A1LMNACYP19A1TSHR | |
| Fluorouracil SCHEMBL21880166 | 0.95 | MAPT (0.95) | MAPTALDH1A1LMNACYP19A1TSHR | |
| Fluorouracil SCHEMBL28803776 | 0.95 | MAPT (0.95) | MAPTALDH1A1LMNACYP19A1TSHR | |
| Fluorouracil SCHEMBL28306216 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105748402-A | Biodegradable drug delivery composition | 杜雷科特公司 | 2016-07-13 | — | — | CN | disclosed |
| CN-105693628-A | Production technology for synthesizing fluorouracil with one-step method | 江苏梅兰化工有限公司 | 2016-06-22 | — | — | CN | disclosed |