Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phosphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | KCNN4 | O15554 | 7/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45520 | 0.97 | CYP1A2 (0.56) | CYP1A2KCNN4NPSR1CYP2D6MAPT | |
| SCHEMBL29559623 | 0.94 | CYP1A2 (0.54) | CYP1A2KCNN4NPSR1CYP2D6MAPT | |
| SCHEMBL10909643 | 0.94 | CYP1A2 (0.54) | CYP1A2KCNN4NPSR1CYP2D6MAPT | |
| SCHEMBL28778133 | 0.94 | CYP1A2 (0.54) | CYP1A2KCNN4NPSR1CYP2D6MAPT | |
| SCHEMBL10403424 | 0.94 | CYP1A2 (0.54) | CYP1A2KCNN4NPSR1CYP2D6MAPT | |
| SCHEMBL7880822 | 0.94 | CYP1A2 (0.54) | CYP1A2KCNN4NPSR1CYP2D6MAPT | |
| SCHEMBL30541207 | 0.94 | CYP1A2 (0.54) | CYP1A2KCNN4NPSR1CYP2D6MAPT | |
| SCHEMBL11522471 | 0.94 | CYP1A2 (0.54) | CYP1A2KCNN4NPSR1CYP2D6MAPT | |
| SCHEMBL29282850 | 0.94 | CYP1A2 (0.54) | CYP1A2KCNN4NPSR1CYP2D6MAPT | |
| SCHEMBL28288580 | 0.94 | CYP1A2 (0.54) | CYP1A2KCNN4NPSR1CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109280331-B | resin composition, coating composition and product thereof | 长春人造树脂厂股份有限公司 | 2019-11-26 | — | — | CN | disclosed |
| CN-110291172-A | Method for reducing permeability of a subterranean formation to water-based fluids | 陶氏环球技术有限责任公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-110054779-A | A kind of polysiloxanes and the preparation method and application thereof containing acid anhydrides | 无锡东润电子材料科技有限公司 | 2019-07-26 | — | — | CN | disclosed |
| CN-109563235-A | Water-soluble α -diol sulfonated epoxy resin composition and preparation method thereof | 陶氏环球技术有限责任公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109280331-A | resin composition, coating composition and product thereof | 长春人造树脂厂股份有限公司 | 2019-01-29 | — | — | CN | disclosed |
| CN-105722928-B | Curable polyurethane coating compositions and methods of making the same | 陶氏环球技术有限责任公司 | 2018-10-26 | — | — | CN | disclosed |
| CN-108570328-A | Liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display assembly | 奇美实业股份有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-108137777-A | Include the coating of single allophanate based on alkoxy silane alkyl isocyanate | 赢创德固赛有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107987848-A | Liquid crystal alignment agent and manufacturing method thereof, liquid crystal alignment film and manufacturing method thereof, and liquid crystal display assembly and manufacturing method thereof | 奇美实业股份有限公司 | 2018-05-04 | — | — | CN | disclosed |
| CN-105969404-B | Liquid crystal aligning agent, liquid crystal alignment film formed by liquid crystal aligning agent and liquid crystal display element | 奇美实业股份有限公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-107787520-A | Hyperplane spin coating carbon material | 布鲁尔科技公司 | 2018-03-09 | — | — | CN | disclosed |
| CN-107245340-A | Liquid crystal aligning agent, liquid crystal alignment film and liquid crystal display element | 奇美实业股份有限公司 | 2017-10-13 | — | — | CN | disclosed |
| CN-107129812-A | Liquid crystal alignment agent and application thereof | 奇美实业股份有限公司 | 2017-09-05 | — | — | CN | disclosed |
| CN-107043630-A | Liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display assembly | 奇美实业股份有限公司 | 2017-08-15 | — | — | CN | disclosed |
| CN-106967445-A | Liquid crystal aligning agent, liquid crystal alignment film and liquid crystal display element | 奇美实业股份有限公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-103476764-B | Process for producing episulfide compound | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2016-05-25 | — | — | CN | disclosed |