Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481796 | 0.81 | CYP11B1 (0.40) | CYP11B1CYP11B2IDO1CYP19A1CYP1A2 | |
| SCHEMBL1765841 | 0.81 | CYP11B1 (0.40) | CYP11B1CYP11B2P2RX7CYP19A1CYP1A2 | |
| SCHEMBL25307807 | 0.79 | CYP11B1 (0.38) | CYP11B1CYP11B2TAAR1NR1I2ADORA3 | |
| SCHEMBL27579878 | 0.79 | CYP11B1 (0.38) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL9235495 | 0.78 | CYP11B1 (0.37) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL10818578 | 0.78 | CYP11B1 (0.37) | CYP11B1CYP11B2IDO1CYP19A1CYP1A2 | |
| SCHEMBL25368193 | 0.78 | CYP11B1 (0.37) | CYP11B1CYP11B2IDO1CYP19A1CYP1A2 | |
| SCHEMBL6613495 | 0.78 | HDAC3 (0.40) | CYP11B1CYP11B2CYP2C19HIF1ATBXAS1 | |
| SCHEMBL9239487 | 0.78 | CYP11B1 (0.37) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL6978240 | 0.77 | CYP11B1 (0.37) | CYP11B1CYP11B2IDO1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108864102-A | ERK inhibitor and application method | 库拉肿瘤学公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-105636586-B | ERK inhibitors and methods of use | 库拉肿瘤学公司 | 2018-05-29 | — | — | CN | disclosed |
| CN-105636586-A | ERK inhibitors and methods of use | ARAXES PHARMA LLC | 2016-06-01 | — | — | CN | disclosed |