Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545178 | 0.88 | MEN1 (0.58) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL20373539 | 0.82 | MEN1 (0.51) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL13841103 | 0.82 | MEN1 (0.49) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL26654625 | 0.81 | MEN1 (0.50) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL30665901 | 0.81 | MEN1 (0.50) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL16431617 | 0.81 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL527222 | 0.78 | MEN1 (0.48) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL3958932 | 0.78 | MEN1 (0.48) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL11638321 | 0.78 | MEN1 (0.54) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL31096947 | 0.77 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105636953-A | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions | NOVARTIS AG | 2016-06-01 | — | — | CN | disclosed |