Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439902 | 1.00 | ROCK2 (0.45) | ROCK2TRPV1TLR8TLR7HCRTR1 | |
| SCHEMBL20975315 | 0.97 | TRPV1 (0.44) | ROCK2TRPV1TLR8TLR7HCRTR1 | |
| SCHEMBL20975319 | 0.97 | TRPV1 (0.44) | ROCK2TRPV1TLR8TLR7HCRTR1 | |
| SCHEMBL16781580 | 0.87 | ROCK2 (0.42) | ROCK2TRPV1TLR8TLR7HCRTR1 | |
| SCHEMBL16486542 | 0.87 | ROCK2 (0.42) | ROCK2TRPV1TLR8TLR7HCRTR1 | |
| SCHEMBL28068160 | 0.85 | ROCK2 (0.45) | ROCK2TRPV1TLR8TLR7HCRTR1 | |
| SCHEMBL30944529 | 0.84 | TRPV1 (0.41) | ROCK2TRPV1TLR8TLR7HCRTR1 | |
| SCHEMBL4413990 | 0.84 | ROCK2 (0.47) | ROCK2TRPV1TLR8TLR7HCRTR1 | |
| SCHEMBL13594838 | 0.84 | ROCK2 (0.47) | ROCK2TRPV1TLR8TLR7HCRTR1 | |
| SCHEMBL16486649 | 0.82 | ROCK2 (0.48) | ROCK2TRPV1TLR8TLR7HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105636612-A | 1- (chloromethyl) -2, 3-dihydro-1H-benzo [ e ] indole dimer antibody-drug conjugate compounds, and methods of use and treatment | GENENTECH INC | 2016-06-01 | — | — | CN | disclosed |