Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.67 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | AKT2 | P31751 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887147 | 1.00 | JAK3 (0.67) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL6743217 | 0.85 | JAK3 (0.67) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL3961208 | 0.84 | JAK3 (0.66) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL3951466 | 0.84 | JAK3 (0.71) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL3959625 | 0.82 | JAK3 (0.68) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL6742185 | 0.81 | JAK3 (0.67) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL2024604 | 0.81 | JAK3 (1.00) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL3956020 | 0.80 | JAK3 (0.65) | JAK3JAK1DOT1LLCKAKT2 | |
| SCHEMBL28379121 | 0.79 | JAK3 (0.69) | JAK3JAK1LCKJAK2 | |
| SCHEMBL28068302 | 0.79 | JAK3 (0.69) | JAK3JAK1LCKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732636-B | Heteroaromatic compounds and their use in medicine | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-105732636-A | Hetero-aromatic compounds and applications thereof in pharmacy | 广东东阳光药业有限公司 | 2016-07-06 | — | — | CN | disclosed |