Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.69 |
| ▸ | JAK2 | O60674 | 6/20 | 0.54 |
| ▸ | LCK | P06239 | 4/20 | 0.52 |
| ▸ | JAK1 | P23458 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28379121 | 1.00 | JAK3 (0.69) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL28379420 | 0.82 | JAK3 (1.00) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL28384574 | 0.82 | JAK3 (1.00) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL13975681 | 0.82 | JAK3 (0.56) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL28068464 | 0.81 | JAK3 (0.65) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL28068350 | 0.79 | JAK3 (0.67) | JAK3JAK2LCKJAK1 | |
| SCHEMBL28887147 | 0.79 | JAK3 (0.67) | JAK3JAK2LCKJAK1 | |
| SCHEMBL6743217 | 0.79 | JAK3 (0.67) | JAK3LCKJAK1 | |
| SCHEMBL15209029 | 0.77 | JAK3 (0.72) | JAK3JAK2LCKJAK1TYK2 | |
| SCHEMBL15208862 | 0.77 | JAK3 (0.72) | JAK3JAK2LCKJAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732636-B | Heteroaromatic compounds and their use in medicine | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-105732636-A | Hetero-aromatic compounds and applications thereof in pharmacy | 广东东阳光药业有限公司 | 2016-07-06 | — | — | CN | disclosed |