Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 5/20 | 0.47 |
| ▸ | TAB1 | Q15750 | 5/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 9/20 | 0.44 |
| ▸ | JAK3 | P52333 | 9/20 | 0.44 |
| ▸ | JAK1 | P23458 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3221026 | 0.82 | CHEK1 (0.49) | MAP3K7TAB1CHEK1JAK2JAK3 | |
| SCHEMBL3224390 | 0.81 | CHEK1 (0.50) | MAP3K7TAB1CHEK1JAK2JAK3 | |
| SCHEMBL12777831 | 0.80 | MAP3K7 (0.56) | MAP3K7TAB1CHEK1JAK2JAK3 | |
| SCHEMBL27409279 | 0.79 | JAK3 (0.46) | JAK2JAK3JAK1SYKCYP2C9 | |
| SCHEMBL179562 | 0.79 | CHEK1 (0.54) | MAP3K7TAB1CHEK1JAK2JAK3 | |
| SCHEMBL157260 | 0.79 | CHEK1 (0.54) | MAP3K7TAB1CHEK1JAK2JAK3 | |
| SCHEMBL155227 | 0.79 | CHEK1 (0.54) | MAP3K7TAB1CHEK1JAK2JAK3 | |
| SCHEMBL16764899 | 0.77 | CHEK1 (0.49) | MAP3K7TAB1CHEK1JAK2JAK3 | |
| SCHEMBL355606 | 0.76 | JAK2 (0.64) | JAK2JAK3 | |
| SCHEMBL21678729 | 0.76 | CHEK1 (0.45) | MAP3K7TAB1CHEK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732636-B | Heteroaromatic compounds and their use in medicine | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-105732636-A | Hetero-aromatic compounds and applications thereof in pharmacy | 广东东阳光药业有限公司 | 2016-07-06 | — | — | CN | disclosed |