Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.46 |
| ▸ | JAK2 | O60674 | 9/20 | 0.46 |
| ▸ | JAK1 | P23458 | 9/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27409275 | 0.81 | LMNA (0.36) | JAK3JAK2JAK1 | |
| SCHEMBL28068449 | 0.79 | MAP3K7 (0.47) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL2080455 | 0.77 | KDM5A (0.37) | — | |
| SCHEMBL2080225 | 0.77 | KDM5A (0.47) | — | |
| SCHEMBL27409285 | 0.77 | CA12 (0.36) | JAK3JAK2 | |
| SCHEMBL1494249 | 0.76 | KDM5A (0.36) | JAK2JAK1 | |
| SCHEMBL27409267 | 0.75 | KDM5A (0.34) | JAK3SYK | |
| SCHEMBL985078 | 0.75 | JAK2 (0.46) | JAK3JAK2 | |
| SCHEMBL649677 | 0.72 | JAK3 (0.65) | JAK3JAK2JAK1SYKCYP2C9 | |
| SCHEMBL653401 | 0.72 | JAK3 (0.58) | JAK3JAK2JAK1SYKCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240209005-A1 | BICYCLIC HETEROARYL BORONATE DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | RIBOSCIENCE LLC | 2024-06-27 | — | — | US | disclosed |
| US-20240209005-A1 | BICYCLIC HETEROARYL BORONATE DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | RIBOSCIENCE LLC | 2024-06-27 | — | — | US | disclosed |
| WO-2022197734-A1 | BICYCLIC HETEROARYL BORONATE DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | RIBOSCIENCE LLC (US) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240209005-A1 | BICYCLIC HETEROARYL BORONATE DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | ENPP1, ENPP3, ENTPD5 | JAK3 3687/4885JAK2 2904/4885JAK1 2740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.