Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.65 |
| ▸ | JAK2 | O60674 | 11/20 | 0.65 |
| ▸ | JAK1 | P23458 | 4/20 | 0.65 |
| ▸ | TYK2 | P29597 | 3/20 | 0.58 |
| ▸ | AKT2 | P31751 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28383701 | 0.82 | JAK3 (0.75) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL20411205 | 0.81 | JAK3 (0.75) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL28068302 | 0.81 | JAK3 (0.69) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL28379121 | 0.81 | JAK3 (0.69) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL28384496 | 0.81 | JAK3 (0.71) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL15170301 | 0.78 | JAK2 (1.00) | JAK3JAK2JAK1 | |
| SCHEMBL15170306 | 0.78 | JAK2 (1.00) | JAK3JAK2JAK1 | |
| SCHEMBL15178734 | 0.78 | JAK2 (1.00) | JAK3JAK2JAK1 | |
| SCHEMBL28068320 | 0.78 | JAK3 (0.69) | JAK3JAK2JAK1AKT2GSK3B | |
| SCHEMBL17951088 | 0.78 | JAK3 (0.69) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732636-B | Heteroaromatic compounds and their use in medicine | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-105732636-A | Hetero-aromatic compounds and applications thereof in pharmacy | 广东东阳光药业有限公司 | 2016-07-06 | — | — | CN | disclosed |