SCHEMBL28068614

SCHEMBL28068614

Cc1c(C(=O)O)ccc(C(Cl)Cl)c1C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM1 Q13255 1/20 0.44
CYP1A2 P05177 1/20 0.37
ACE2 Q9BYF1 2/20 0.36
TSHR P16473 2/20 0.35
HAAO P46952 1/20 0.34
GABRP O00591 1/20 0.34
GABRD O14764 1/20 0.34
GABRA1 P14867 1/20 0.34
GABRB1 P18505 1/20 0.34
GABRG2 P18507 1/20 0.34
GABRB3 P28472 1/20 0.34
GABRA5 P31644 1/20 0.34
GABRA3 P34903 1/20 0.34
GABRA2 P47869 1/20 0.34
GABRB2 P47870 1/20 0.34
GABRA4 P48169 1/20 0.34
GABRE P78334 1/20 0.34
GABRA6 Q16445 1/20 0.34
GABRG1 Q8N1C3 1/20 0.34
GABRG3 Q99928 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27985345 0.87 GRM1 (0.42) GRM1CYP1A2ACE2TSHRHAAO
SCHEMBL27821540 0.83 GRM1 (0.45) GRM1CYP1A2ACE2TSHRHAAO
SCHEMBL27588019 0.83 ACE2 (0.47) GRM1CYP1A2ACE2TSHRHAAO
SCHEMBL28753748 0.81 GRM1 (0.47) GRM1CYP1A2ACE2TSHRHAAO
SCHEMBL6334298 0.78 CYP1A2 (0.48) GRM1CYP1A2TSHRHAAOGABRP
SCHEMBL28134184 0.77 GRM1 (0.41) GRM1CYP1A2ACE2TSHRALDH1A1
SCHEMBL27749718 0.76 TYR (0.42) GRM1ACE2MYCALDH1A1AKR1C3
SCHEMBL27749720 0.76 TYR (0.42) GRM1ACE2MYCALDH1A1AKR1C3
SCHEMBL27280575 0.75 DPP4 (0.52) CYP1A2TSHRMYCALDH1A1NR4A1
SCHEMBL195882 0.74 CYP1A2 (0.44) GRM1CYP1A2TSHRHAAOGABRP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102834378-B Biphenyl-substituted cyclic keto-enols 拜耳知识产权有限责任公司 2016-07-06 CN disclosed