Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | PNMT | P11086 | 2/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL27716220 | 0.85 | TSHR (0.60) | TSHRPNMTTAS1R3TAS1R1TAS1R2 | |
| Alcohol SCHEMBL29018751 | 0.84 | TSHR (0.74) | TSHRPNMTTAS1R3TAS1R1TAS1R2 | |
| 1,2-Dichlorobenzene SCHEMBL9003449 | 0.82 | TSHR (0.62) | TSHRPNMTTP53TAAR1IDO1 | |
| SCHEMBL3991309 | 0.82 | TSHR (0.61) | TSHRPNMTMEN1KMT2ACYP1A2 | |
| SCHEMBL23239 | 0.82 | — | — | |
| Hexane SCHEMBL28166224 | 0.81 | DRD3 (0.49) | TSHRPNMTTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL28189130 | 0.79 | TSHR (0.52) | TSHRPNMTMEN1KMT2ACYP1A2 | |
| Fluoromethane SCHEMBL28306611 | 0.79 | TSHR (0.52) | TSHRPNMTMEN1KMT2ACYP1A2 | |
| Ether SCHEMBL28856080 | 0.79 | KDM4E (0.47) | TSHRPNMTTAS1R3TAS1R1TAS1R2 | |
| Fluoride SCHEMBL28376896 | 0.78 | TSHR (0.58) | TSHRPNMTMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105566309-A | Method for synthesizing Luliconazole | HUNAN TRADITIONAL CHINESE MEDICAL COLLEGE | 2016-05-11 | — | — | CN | disclosed |