Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 12/20 | 0.68 |
| ▸ | F11 | P03951 | 2/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.47 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.47 |
| ▸ | CTSA | P10619 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16397683 | 0.94 | CFD (0.61) | CFDF11SUCNR1TPSB2CTSA | |
| SCHEMBL16396871 | 0.92 | CFD (0.62) | CFDF11SUCNR1TPSB2CTSA | |
| SCHEMBL16397161 | 0.91 | CFD (0.78) | CFDF11SUCNR1TPSB2CTSA | |
| SCHEMBL16397262 | 0.89 | CFD (0.59) | CFDF11SUCNR1TPSB2CTSA | |
| SCHEMBL16397441 | 0.87 | CFD (0.61) | CFDF11SUCNR1TPSB2CTSA | |
| SCHEMBL16396602 | 0.87 | CFD (0.63) | CFDF11SUCNR1TPSB2CTSA | |
| SCHEMBL16397300 | 0.84 | CFD (0.59) | CFDF11SUCNR1TPSB2CTSA | |
| SCHEMBL16397190 | 0.83 | CFD (0.58) | CFDF11SUCNR1TPSB2CTSA | |
| SCHEMBL16396922 | 0.81 | CFD (1.00) | CFDF11SUCNR1TPSB2CNR2 | |
| SCHEMBL16410469 | 0.75 | SUCNR1 (0.66) | CFDF11SUCNR1TPSB2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555766-A | Aminomethyl-biaryl derivatives as complement factor D inhibitors and uses thereof | NOVARTIS AG | 2016-05-04 | — | — | CN | disclosed |