Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27718558 | 0.88 | TAAR1 (0.45) | GLAHCAR2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27574865 | 0.88 | GLA (0.53) | GLAHCAR2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27486398 | 0.81 | MAOB (0.52) | GLAHCAR2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28513032 | 0.77 | SMN1; SMN2 (0.51) | NPC1ALDH1A1LMNAHTTRAB9A | |
| SCHEMBL9347048 | 0.77 | IDO1 (0.64) | HCAR2MAOBIDO1AGXTMAOA | |
| SCHEMBL27708689 | 0.76 | LMNA (0.49) | GLACYP1A2CYP2C19NPC1ALDH1A1 | |
| SCHEMBL27859352 | 0.76 | NPC1 (0.48) | CYP2C19NPC1LMNA | |
| SCHEMBL28776560 | 0.76 | TYR (0.53) | — | |
| SCHEMBL27820672 | 0.74 | MEN1 (0.43) | GLACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL27589965 | 0.74 | ANO1 (0.45) | CYP1A2CYP3A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555766-A | Aminomethyl-biaryl derivatives as complement factor D inhibitors and uses thereof | NOVARTIS AG | 2016-05-04 | — | — | CN | disclosed |