Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31444807 | 0.87 | NPC1 (0.57) | SMN1; SMN2HTTNPC1RAB9AKMT2A | |
| SCHEMBL6692876 | 0.87 | NPC1 (0.57) | SMN1; SMN2HTTNPC1RAB9AKMT2A | |
| SCHEMBL5197892 | 0.87 | NPC1 (0.57) | SMN1; SMN2HTTNPC1RAB9AKMT2A | |
| SCHEMBL5145754 | 0.84 | KMT2A (0.62) | SMN1; SMN2HTTNPC1RAB9AKMT2A | |
| SCHEMBL23857904 | 0.84 | FNTA (0.67) | SMN1; SMN2HTTNPC1RAB9AKMT2A | |
| SCHEMBL11221078 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2HTTNPC1RAB9AKMT2A | |
| SCHEMBL9912441 | 0.81 | NPC1 (0.58) | SMN1; SMN2HTTNPC1RAB9AKMT2A | |
| SCHEMBL28172169 | 0.81 | NPC1 (0.58) | SMN1; SMN2HTTNPC1RAB9AKMT2A | |
| SCHEMBL28745974 | 0.81 | GAA (0.79) | SMN1; SMN2HTTNPC1RAB9AKMT2A | |
| SCHEMBL7567258 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555766-A | Aminomethyl-biaryl derivatives as complement factor D inhibitors and uses thereof | NOVARTIS AG | 2016-05-04 | — | — | CN | disclosed |