Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 8/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.42 |
| ▸ | DNMT3A | Q9Y6K1 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16586076 | 0.86 | PIK3CD (0.58) | EGFRAURKADNMT1DNMT3APIK3CD | |
| SCHEMBL16596382 | 0.82 | PIK3CD (0.60) | EGFRAURKADNMT1DNMT3APIK3CD | |
| SCHEMBL28049941 | 0.78 | MAOA (0.50) | EGFRAURKAMAOAMAOBPIK3CD | |
| SCHEMBL17994857 | 0.76 | EGFR (0.61) | EGFRAURKADNMT1DNMT3APIK3CD | |
| SCHEMBL12694408 | 0.76 | EGFR (0.68) | EGFRAURKAAURKBKDR | |
| SCHEMBL17994858 | 0.74 | EGFR (0.58) | EGFRAURKADNMT1DNMT3APIK3CD | |
| SCHEMBL19563559 | 0.72 | AURKA (0.51) | EGFRAURKADNMT1DNMT3APIK3CD | |
| SCHEMBL1938919 | 0.70 | AURKA (0.54) | EGFRAURKADNMT1DNMT3AMEN1 | |
| SCHEMBL27969044 | 0.70 | MAOA (0.50) | MAOAMAOBMEN1MAPTKMT2A | |
| SCHEMBL1939067 | 0.70 | AURKA (0.81) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555781-A | Quinazoline derivatives and their use as DNA methyltransferase inhibitors | PF MEDICAMENT | 2016-05-04 | — | — | CN | disclosed |