Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28070642 | 0.91 | GAA (0.35) | PIM1PIM3PIM2ALDH1A1KMT2A | |
| SCHEMBL2523293 | 0.80 | ALDH1A1 (0.37) | PIM1PIM3PIM2ALDH1A1KMT2A | |
| SCHEMBL2515867 | 0.77 | MEN1 (0.39) | ALDH1A1KMT2AMEN1GAAMAPT | |
| SCHEMBL2515869 | 0.77 | MEN1 (0.39) | ALDH1A1KMT2AMEN1GAAMAPT | |
| SCHEMBL2522631 | 0.77 | MEN1 (0.39) | ALDH1A1KMT2AMEN1GAAMAPT | |
| SCHEMBL14800490 | 0.77 | PIM1 (0.43) | PIM1ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL16504578 | 0.76 | MEN1 (0.40) | PIM1PIM3PIM2ALDH1A1KMT2A | |
| SCHEMBL14800680 | 0.76 | PIM2 (0.44) | PIM1PIM3PIM2ALDH1A1KMT2A | |
| SCHEMBL2520823 | 0.76 | ALDH1A1 (0.50) | ALDH1A1GAAMAPTLMNAPOLB | |
| SCHEMBL2518353 | 0.75 | MAPT (0.38) | PIM1PIM3PIM2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658653-A | Furo- and thieno-pyridine carboxamide compounds useful as PIM kinase inhibitors | 因赛特公司 | 2016-06-08 | — | — | CN | disclosed |