Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 15/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 12/20 | 0.42 |
| ▸ | PIM1 | P11309 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28070601 | 1.00 | PIM2 (0.42) | PIM2PIM3PIM1KDM4EALDH1A1 | |
| SCHEMBL28070539 | 0.86 | MAPT (0.45) | ALDH1A1GAANTMT1MAPT | |
| SCHEMBL15874967 | 0.84 | PIM2 (0.44) | PIM2PIM3PIM1KDM4EALDH1A1 | |
| SCHEMBL15874969 | 0.84 | PIM2 (0.44) | PIM2PIM3PIM1KDM4EALDH1A1 | |
| SCHEMBL13719758 | 0.84 | CDK8 (0.40) | PIM2PIM3PIM1NTMT1 | |
| SCHEMBL13719598 | 0.83 | CDK8 (0.40) | PIM2PIM3PIM1NTMT1 | |
| SCHEMBL13822630 | 0.82 | CDK8 (0.39) | NTMT1 | |
| SCHEMBL13719741 | 0.82 | CDK8 (0.39) | NTMT1 | |
| SCHEMBL31302348 | 0.82 | KDM4E (0.40) | PIM2PIM3PIM1KDM4EALDH1A1 | |
| SCHEMBL31302417 | 0.82 | KDM4E (0.40) | PIM2PIM3PIM1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658653-A | Furo- and thieno-pyridine carboxamide compounds useful as PIM kinase inhibitors | 因赛特公司 | 2016-06-08 | — | — | CN | disclosed |