Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28070620 | 0.94 | MAPT (0.41) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL28070569 | 0.94 | MAPT (0.41) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL28070486 | 0.92 | MAPT (0.41) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL28070619 | 0.86 | PIM2 (0.42) | MAPTALDH1A1GAANTMT1 | |
| SCHEMBL28070601 | 0.86 | PIM2 (0.42) | MAPTALDH1A1GAANTMT1 | |
| SCHEMBL13719960 | 0.83 | SMN1; SMN2 (0.36) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL13719545 | 0.82 | SMN1; SMN2 (0.36) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL13719661 | 0.81 | SMN1; SMN2 (0.35) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL4565720 | 0.81 | ALDH1A1 (0.42) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL4433633 | 0.81 | ALDH1A1 (0.42) | MAPTALDH1A1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658653-A | Furo- and thieno-pyridine carboxamide compounds useful as PIM kinase inhibitors | 因赛特公司 | 2016-06-08 | — | — | CN | disclosed |