Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Fluorobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ1 known ✓ | P51787 | 1/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 7/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorobenzene SCHEMBL27509339 | 0.91 | NQO2 (0.49) | KCNN4PARP1PKMBLMRECQL | |
| Fluorobenzene SCHEMBL10885260 | 0.87 | KCNN4 (0.56) | KCNN4PARP1PKMBLMRECQL | |
| Fluorobenzene SCHEMBL27399872 | 0.87 | KCNN4 (0.56) | KCNN4PARP1PKMBLMRECQL | |
| Fluorobenzene SCHEMBL5865256 | 0.87 | KCNN4 (0.48) | KCNN4PARP1TSHRNPC1RAB9A | |
| Fluorobenzene SCHEMBL28144868 | 0.87 | KCNN4 (0.48) | KCNN4PARP1TSHRNPC1RAB9A | |
| Fluorobenzene SCHEMBL27602373 | 0.83 | KCNN4 (0.42) | KCNN4PKMF2TSHRCYP2C19 | |
| Fluorobenzene SCHEMBL28291780 | 0.82 | KCNN4 (0.52) | KCNN4PARP1PKMBLMRECQL | |
| Fluorobenzene SCHEMBL28200701 | 0.79 | KCNN4 (0.48) | KCNN4PARP1PKMBLMRECQL | |
| Benzene SCHEMBL27533838 | 0.78 | ACHE (0.46) | PARP1PKMBLMRECQLF2 | |
| Fluorobenzene SCHEMBL4355920 | 0.76 | KCNN4 (0.40) | KCNN4POLBCYP3A4MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105669642-B | Preparation method of loflupridine hydrochloride | 江苏天士力帝益药业有限公司 | 2020-06-09 | — | — | CN | claimed |
| CN-105669642-A | Revaprzan hydrochloride preparation method | 江苏天士力帝益药业有限公司 | 2016-06-15 | — | — | CN | claimed |
| CN-105669642-B | Preparation method of loflupridine hydrochloride | 江苏天士力帝益药业有限公司 | 2020-06-09 | — | — | CN | disclosed |
| CN-105669642-A | Revaprzan hydrochloride preparation method | 江苏天士力帝益药业有限公司 | 2016-06-15 | — | — | CN | disclosed |