Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551822 | 0.85 | EPHX2 (0.50) | EPHX2CYP3A4TSHRNFKB1THPO | |
| SCHEMBL20129651 | 0.85 | EPHX2 (0.52) | EPHX2CYP3A4TSHRNFKB1THPO | |
| SCHEMBL2420105 | 0.84 | EPHX2 (0.49) | EPHX2CYP3A4TSHRNFKB1THPO | |
| SCHEMBL4820196 | 0.81 | EPHX2 (0.46) | DRD4EPHX2CYP3A4TSHRNFKB1 | |
| SCHEMBL28082095 | 0.78 | EPHX2 (0.49) | EPHX2HTR2CHTR6PLD1KDM4E | |
| SCHEMBL4807185 | 0.78 | EPHX2 (0.49) | EPHX2CYP3A4HTR2CLMNA | |
| SCHEMBL20141849 | 0.78 | EPHX2 (0.43) | DRD4EPHX2CYP3A4TSHRNFKB1 | |
| SCHEMBL20129610 | 0.78 | EPHX2 (0.43) | DRD4EPHX2CYP3A4TSHRNFKB1 | |
| SCHEMBL20141065 | 0.78 | EPHX2 (0.43) | DRD4EPHX2CYP3A4TSHRNFKB1 | |
| Piperazine SCHEMBL6684567 | 0.77 | EPHX2 (0.48) | EPHX2CYP3A4HTR2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814056-B | purine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2017-10-10 | — | — | CN | disclosed |
| CN-105829307-A | TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB生物制药私人有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105814025-A | Tetrahydrobenzimidazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814051-A | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |