Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 10/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 6/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10447781 | 0.79 | NOTUM (0.78) | NOTUMCYP19A1KEAP1 | |
| SCHEMBL25045427 | 0.77 | NOTUM (0.68) | NOTUMCYP19A1KEAP1 | |
| SCHEMBL28166936 | 0.77 | NOTUM (0.67) | NOTUMCYP19A1HTTKMT2AKEAP1 | |
| SCHEMBL28266475 | 0.76 | RXRA (0.52) | NOTUMRXRAGRIN1GRIN2BKEAP1 | |
| SCHEMBL16102370 | 0.76 | NOTUM (0.58) | NOTUMCYP19A1RXRAGRIN1GRIN2B | |
| SCHEMBL28266360 | 0.75 | NOTUM (0.60) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL29084891 | 0.75 | NOTUM (0.65) | NOTUMCYP19A1HTTKMT2AKEAP1 | |
| SCHEMBL21777006 | 0.74 | NOTUM (1.00) | NOTUMCYP19A1KMT2AKEAP1 | |
| SCHEMBL13666599 | 0.72 | CYP19A1 (0.77) | NOTUMCYP19A1ALDH1A1MEN1LMNA | |
| SCHEMBL29378371 | 0.71 | CYP19A1 (0.53) | NOTUMCYP19A1MEN1KMT2AKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103596937-B | Substituted benzamide derivatives | 霍夫曼-拉罗奇有限公司 | 2016-06-29 | — | — | CN | disclosed |