Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.67 |
| ▸ | TYK2 | P29597 | 7/20 | 0.67 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.62 |
| ▸ | JAK1 | P23458 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SMO | Q99835 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755776 | 0.87 | JAK2 (0.68) | JAK2TYK2CYP11B2ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL9197573 | 0.86 | ROCK2 (0.79) | JAK2TYK2CYP11B2ROCK2ROCK1 | |
| SCHEMBL2899135 | 0.82 | MEN1 (0.67) | JAK2TYK2CYP11B2ROCK2ROCK1 | |
| SCHEMBL12795370 | 0.82 | ROCK2 (0.56) | JAK2TYK2CYP11B2ROCK2ROCK1 | |
| SCHEMBL27529279 | 0.82 | ROCK2 (0.56) | JAK2TYK2CYP11B2ROCK2ROCK1 | |
| SCHEMBL1665446 | 0.81 | JAK2 (0.67) | JAK2TYK2ROCK2ROCK1JAK1 | |
| SCHEMBL13322124 | 0.81 | TYK2 (0.67) | JAK2TYK2CYP11B2HTTALDH1A1 | |
| SCHEMBL28072916 | 0.81 | HTT (0.67) | JAK2TYK2CYP11B2JAK1HTT | |
| SCHEMBL2892111 | 0.81 | HTT (0.56) | JAK2TYK2CYP11B2ROCK2ROCK1 | |
| SCHEMBL15271178 | 0.80 | JAK2 (1.00) | JAK2TYK2CYP11B2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579044-A | Use of dianhydrogalactitol and analogs and derivatives thereof for treating recurrent malignant glioma or progressive secondary brain tumor | DEL MAR PHARMACEUTICALS | 2016-05-11 | — | — | CN | disclosed |