Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 10/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28073675 | 0.85 | CRACR2A (0.51) | CRACR2AORAI1KCNJ6KCNJ3 | |
| SCHEMBL27887592 | 0.82 | CRACR2A (0.54) | CRACR2AORAI1 | |
| SCHEMBL27887546 | 0.79 | CRACR2A (0.54) | CRACR2APTGS1PTGS2MAPT | |
| SCHEMBL28073678 | 0.78 | CRACR2A (0.51) | CRACR2AORAI1 | |
| SCHEMBL28073661 | 0.77 | CRACR2A (0.44) | CRACR2AORAI1 | |
| SCHEMBL1668268 | 0.75 | CRACR2A (0.38) | CRACR2ATRPC3ORAI1TRPC5KCNJ6 | |
| SCHEMBL27887542 | 0.75 | CRACR2A (0.49) | CRACR2ATRPC3ORAI1TRPC5PTGS1 | |
| SCHEMBL27904320 | 0.75 | CRACR2A (0.49) | CRACR2ATRPC3ORAI1TRPC5PTGS1 | |
| SCHEMBL27887548 | 0.74 | CRACR2A (0.53) | CRACR2AORAI1 | |
| SCHEMBL1668271 | 0.73 | CRACR2A (0.35) | CRACR2ATRPC3ORAI1TRPC5KCNJ6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102834382-B | The pyrazole derivatives of calcium channel modulators is activated as calcium release | 理森制药股份公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-102834382-A | Pyrazole derivatives as modulators of calcium release-activated calcium channel | RHIZEN PHARMACEUTICALS S A | 2012-12-19 | — | — | CN | disclosed |