Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 8/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1668268 | 0.75 | CRACR2A (0.38) | CRACR2AHPGDSMN1; SMN2GAATRPC3 | |
| SCHEMBL28073663 | 0.73 | CRACR2A (0.38) | CRACR2AHPGDSMN1; SMN2GAAPTGS1 | |
| SCHEMBL1668269 | 0.70 | CRACR2A (0.50) | CRACR2AHPGDGAAKDM4EALDH1A1 | |
| SCHEMBL1885456 | 0.67 | CRACR2A (0.76) | CRACR2AHPGDGAAKDM4EALDH1A1 | |
| SCHEMBL12298698 | 0.65 | CNR1 (0.48) | CRACR2ASMN1; SMN2PTGS2ALDH1A1KCNJ6 | |
| SCHEMBL1668102 | 0.62 | EPHX2 (0.74) | CRACR2ASMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL31465902 | 0.62 | P2RY14 (0.40) | GAAKDM4EMAPT | |
| SCHEMBL31466256 | 0.61 | GPR119 (0.54) | HPGDSMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL2557636 | 0.60 | NPC1 (0.63) | SMN1; SMN2ALDH1A1MAPTPOLBKCNJ6 | |
| SCHEMBL7242808 | 0.59 | ORAI1 (0.60) | PTGS2KDM4EMAPTTRPC3ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509955-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011042797-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL | ICOZEN THERAPEUTICS PVT. LTD. (IN) | 2011-04-14 | — | — | WO | disclosed |