SCHEMBL28074441

SCHEMBL28074441

C=Cc1ccc(-c2cccc3c4ccccc4n(CC)c23)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.42
HTT P42858 4/20 0.42
POLB P06746 1/20 0.42
PKM P14618 1/20 0.42
SRC P12931 2/20 0.40
ALDH1A1 P00352 4/20 0.40
PTGER4 P35408 1/20 0.39
HPGD P15428 4/20 0.38
MAPT P10636 2/20 0.38
HSD17B10 Q99714 2/20 0.38
MAPK1 P28482 2/20 0.38
MEN1 O00255 1/20 0.38
HBB P68871 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
LMNA P02545 4/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
USP2 O75604 1/20 0.38
TSHR P16473 1/20 0.38
CASP1 P29466 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16865754 0.89 ALDH1A1 (0.49) KDM4EHTTPOLBPKMALDH1A1
SCHEMBL16865764 0.87 ALDH1A1 (0.47) KDM4EHTTPOLBPKMALDH1A1
SCHEMBL27900579 0.84 KDM4E (0.49) KDM4EHTTPOLBALDH1A1HPGD
SCHEMBL23360792 0.84 KDM4E (0.52) KDM4EHTTPOLBPKMSRC
SCHEMBL20549527 0.83 KDM4E (0.44) KDM4EHTTPOLBPKMSRC
SCHEMBL28571940 0.82 MAPT (0.47) KDM4EHTTALDH1A1PTGER4HPGD
SCHEMBL17885720 0.81 ALDH1A1 (0.53) KDM4EHTTPOLBPKMALDH1A1
SCHEMBL17565577 0.79 KDM4E (0.55) KDM4EHTTPOLBPKMSRC
SCHEMBL27968213 0.79 NPY5R (0.52) KDM4EHTTPOLBALDH1A1HPGD
SCHEMBL17565574 0.79 KDM4E (0.48) KDM4EHTTPOLBPKMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109053549-B Two-photon fluorescent probe for positioning mitochondria to detect viscosity and synthetic method and application thereof 济南大学 2020-08-11 CN disclosed
CN-105646367-B Bipolar compound derived from cis-stilbene/fluorene spirochete 彩丰精技股份有限公司 2018-05-22 CN disclosed
CN-105693553-B Cis-stilbene/fluorene derived photoelectric material 彩丰精技股份有限公司 2018-01-02 CN disclosed
CN-105693553-A Cis-stilbene/fluorene derived photoelectric material 彩丰精技股份有限公司 2016-06-22 CN disclosed
CN-105646367-A Bipolar compound derived from cis-stilbene/fluorene spirochete 彩丰精技股份有限公司 2016-06-08 CN disclosed