Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Thiophene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiophene SCHEMBL1712386 | 0.95 | — | — | |
| Thiophene SCHEMBL623718 | 0.95 | — | — | |
| Thiophene SCHEMBL28371819 | 0.95 | — | — | |
| Thiophene SCHEMBL225070 | 0.95 | — | — | |
| Thiophene SCHEMBL4897121 | 0.95 | — | — | |
| Thiophene SCHEMBL27926242 | 0.95 | — | — | |
| Thiophene SCHEMBL4897113 | 0.95 | — | — | |
| Thiophene SCHEMBL28706005 | 0.91 | — | — | |
| Thiophene SCHEMBL25248961 | 0.90 | — | — | |
| Bromide SCHEMBL9648369 | 0.90 | TP53 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641898-A | For treat nerve and neurodegenerative disease 5,7- dihydro-pyrrole simultaneously-pyridine derivate | 辉瑞公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-108699080-A | 6, 7-dihydro-5H-pyrazolo [5,1-b ] [1,3] oxazine-2-carboxamide compounds | 辉瑞公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-107787322-A | Tricyclic compound and their purposes as phosphodiesterase inhibitors | 辉瑞大药厂 | 2018-03-09 | — | — | CN | disclosed |
| CN-107074843-A | heteroaromatic compounds and their use as dopamine D1 ligands | 辉瑞公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-104395315-B | 4- (substituted amino) -7H-pyrrolo [ 2,3-d ] pyrimidines as LRRK2 inhibitors | 辉瑞大药厂 | 2016-08-17 | — | — | CN | disclosed |
| CN-105732639-A | Novel 4-(Substituted Amino)-7H-Pyrrolo[2,3-d] Pyrimidines As LRRK2 Inhibitors | 辉瑞大药厂 | 2016-07-06 | — | — | CN | disclosed |