⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045911 | 0.76 | — | — | |
| SCHEMBL29004078 | 0.73 | — | — | |
| SCHEMBL1033082 | 0.72 | — | — | |
| SCHEMBL1030843 | 0.72 | — | — | |
| SCHEMBL623292 | 0.72 | — | — | |
| SCHEMBL1028075 | 0.71 | — | — | |
| SCHEMBL1028572 | 0.71 | — | — | |
| SCHEMBL19508366 | 0.71 | — | — | |
| SCHEMBL6663608 | 0.71 | — | — | |
| SCHEMBL12216598 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829318-B | Spiropiperidines or spiropyrrolidines as MDM2 inhibitor | 哈德森生物医药有限公司 | 2018-10-02 | — | — | CN | disclosed |
| CN-108289866-A | MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF | 纳维托制药有限公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-105829318-A | Spiropyrrolidines as MDM2 Inhibitors | 哈德森生物医药有限公司 | 2016-08-03 | — | — | CN | disclosed |