SCHEMBL28075326

SCHEMBL28075326

O=C(O)c1cc(C(=O)O)cc(-c2ccc(C(=O)O)c3ccccc23)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 2/20 0.46
KDM4E B2RXH2 4/20 0.44
HSD17B10 Q99714 2/20 0.44
CYP2C9 P11712 2/20 0.44
CDC25A P30304 1/20 0.44
CDC25B P30305 1/20 0.44
HPGD P15428 1/20 0.44
TSHR P16473 1/20 0.44
ALOX12 P18054 1/20 0.44
ATIC P31939 1/20 0.44
NR4A1 P22736 1/20 0.44
NR4A2 P43354 1/20 0.44
NR4A3 Q92570 1/20 0.44
TYMS P04818 1/20 0.44
CYP2C8 P10632 1/20 0.43
MCL1 Q07820 1/20 0.43
ACMSD Q8TDX5 1/20 0.43
KMO O15229 1/20 0.43
POLB P06746 2/20 0.42
RECQL P46063 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16488681 0.91 DHODH (0.53) DHODHKDM4EHSD17B10CYP2C9HPGD
SCHEMBL17177742 0.89 HSD17B10 (0.50) KDM4EHSD17B10CYP2C9CDC25ACDC25B
SCHEMBL17164118 0.83 NR4A1 (0.52) KDM4EHSD17B10CYP2C9HPGDTSHR
Isophthalic Acid SCHEMBL7177919 0.81 KDM4E (0.58) KDM4EHSD17B10CYP2C9HPGDTSHR
SCHEMBL27945753 0.81 HPGD (0.43) KDM4EHSD17B10CYP2C9HPGDTSHR
SCHEMBL1821515 0.80 NR4A1 (0.58) KDM4EHSD17B10CYP2C9CDC25BHPGD
SCHEMBL29977753 0.80 NR4A1 (0.58) KDM4EHSD17B10CYP2C9CDC25BHPGD
SCHEMBL28910860 0.79 DHODH (0.50) DHODHCYP2C9TSHRALOX12KMO
SCHEMBL27945754 0.79 AKR1C2 (0.46) DHODHKDM4EHSD17B10CYP2C9HPGD
Terephthalic Acid SCHEMBL23387395 0.78 TSHR (0.59) KDM4EHSD17B10CYP2C9CDC25ACDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105601472-A Preparation method of novel 5-[4-(1-carboxyl naphthyl)]-isophthalic acid UNIV ZUNYI MEDICAL 2016-05-25 CN disclosed
CN-105601472-A Preparation method of novel 5-[4-(1-carboxyl naphthyl)]-isophthalic acid UNIV ZUNYI MEDICAL 2016-05-25 CN disclosed