Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Oxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Oxide SCHEMBL19329203 | 0.94 | MAPK1 (0.36) | MAPK1TP53NFKB1CYP2C19THPO | |
| Propylene Oxide SCHEMBL7051815 | 0.94 | — | — | |
| Propylene Oxide SCHEMBL21222708 | 0.94 | MAPK1 (0.36) | MAPK1TP53NFKB1CYP2C19THPO | |
| Propylene Oxide SCHEMBL28276668 | 0.90 | — | — | |
| Propylene Oxide SCHEMBL28276667 | 0.90 | MAPK1 (0.35) | MAPK1TP53NFKB1CYP2C19THPO | |
| Propylene Oxide SCHEMBL11181636 | 0.86 | TDP1 (0.33) | MAPK1TP53NFKB1CYP2C19THPO | |
| Acetic Acid SCHEMBL3810967 | 0.84 | — | — | |
| Methacrylic Acid SCHEMBL29284830 | 0.84 | ALDH1A1 (0.41) | ALDH1A1 | |
| Propylene Oxide SCHEMBL28821858 | 0.83 | CHRM2 (0.36) | LMNASMN1; SMN2CHRM2CHRM5CHRM3 | |
| Propylene Oxide SCHEMBL1029128 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102858815-B | Polyacrylic acid (salt), polyacrylic acid (salt) water-absorbent resin and manufacture method thereof | 株式会社日本触媒 | 2016-07-06 | — | — | CN | disclosed |