Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.66 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28076015 | 0.89 | LRRK2 (0.68) | LRRK2 | |
| SCHEMBL28075840 | 0.89 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL28075939 | 0.85 | LRRK2 (0.64) | LRRK2 | |
| SCHEMBL28830378 | 0.82 | LRRK2 (0.65) | LRRK2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL28075940 | 0.82 | LRRK2 (0.67) | LRRK2ALDH1A1MAPK1 | |
| SCHEMBL14059161 | 0.81 | LRRK2 (0.65) | LRRK2DHFRKDM4EALDH1A1LMNA | |
| SCHEMBL28075841 | 0.80 | LRRK2 (0.61) | LRRK2 | |
| SCHEMBL14059158 | 0.79 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL28075853 | 0.78 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL28075964 | 0.78 | LRRK2 (0.61) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | claimed |
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |