Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 18/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28075937 | 0.85 | LRRK2 (0.66) | LRRK2LMNACLK4PDGFRA | |
| SCHEMBL28076035 | 0.85 | LRRK2 (0.50) | LRRK2CSF1RPDGFRA | |
| SCHEMBL28075920 | 0.82 | LRRK2 (0.66) | LRRK2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL28830377 | 0.82 | LRRK2 (0.64) | LRRK2CSF1RPDGFRA | |
| SCHEMBL28075964 | 0.81 | LRRK2 (0.61) | LRRK2CSF1RPDGFRA | |
| SCHEMBL28075841 | 0.81 | LRRK2 (0.61) | LRRK2CSF1RPDGFRA | |
| SCHEMBL14059261 | 0.81 | LRRK2 (0.64) | LRRK2ALDH1A1HSD17B10 | |
| SCHEMBL14059975 | 0.79 | LRRK2 (1.00) | LRRK2CSF1RPDGFRA | |
| SCHEMBL28075840 | 0.78 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL28075842 | 0.78 | LRRK2 (0.61) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | claimed |
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |