Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 4/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | LGMN | Q99538 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20189313 | 0.83 | GSK3A (0.47) | MAPTGSK3AATRGSK3BPIM1 | |
| SCHEMBL30051838 | 0.83 | GSK3A (0.47) | MAPTGSK3AATRGSK3BPIM1 | |
| SCHEMBL30309939 | 0.77 | MAPT (0.55) | MAPTATRKDM4EALDH1A1LMNA | |
| SCHEMBL14881721 | 0.77 | MAPT (0.55) | MAPTATRKDM4EALDH1A1LMNA | |
| SCHEMBL13354904 | 0.76 | ROCK2 (0.50) | MAPTROCK1CDC42BPBROCK2PIM1 | |
| SCHEMBL14216367 | 0.76 | ROCK2 (0.50) | MAPTROCK1CDC42BPBROCK2PIM1 | |
| SCHEMBL14216365 | 0.76 | ROCK2 (0.50) | MAPTROCK1CDC42BPBROCK2PIM1 | |
| SCHEMBL4398719 | 0.75 | MAPT (0.45) | MAPTROCK1CDC42BPBROCK2PIM1 | |
| SCHEMBL20189967 | 0.75 | MAPT (0.54) | MAPTROCK1CDC42BPBROCK2PIM1 | |
| SCHEMBL15784035 | 0.75 | ATR (0.43) | MAPTCHEK1CHEK2NUDT1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105849098-A | Gsk-3 inhibitors | 百时美施贵宝公司 | 2016-08-10 | — | — | CN | disclosed |