Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 3/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28076020 | 0.80 | LRRK2 (0.64) | LRRK2ERN1GSK3BPRKCDCSF1R | |
| SCHEMBL28950431 | 0.78 | LRRK2 (0.46) | LRRK2GSK3BCHEK1 | |
| SCHEMBL28075955 | 0.77 | LRRK2 (0.67) | LRRK2CSF1R | |
| SCHEMBL28075964 | 0.72 | LRRK2 (0.61) | LRRK2CSF1R | |
| SCHEMBL28075910 | 0.68 | LRRK2 (0.48) | LRRK2GSK3BPRKCDCSF1RCDK1 | |
| SCHEMBL28075846 | 0.68 | LRRK2 (0.48) | LRRK2GSK3BPRKCDCSF1RCDK1 | |
| SCHEMBL28076036 | 0.68 | LRRK2 (0.66) | LRRK2CSF1R | |
| SCHEMBL14060221 | 0.66 | LRRK2 (0.65) | LRRK2GSK3BPRKCAPRKCDCSF1R | |
| SCHEMBL14059972 | 0.65 | LRRK2 (1.00) | LRRK2CSF1R | |
| SCHEMBL28830340 | 0.65 | LRRK2 (0.61) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | claimed |
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |