Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | QDPR | P09417 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14060221 | 0.80 | LRRK2 (0.65) | LRRK2AAK1GSK3BGSK3APRKACA | |
| SCHEMBL28075952 | 0.78 | LRRK2 (0.48) | LRRK2GSK3BCHEK1 | |
| SCHEMBL14059209 | 0.77 | LRRK2 (0.64) | LRRK2AAK1GSK3BGSK3APRKACA | |
| SCHEMBL28075955 | 0.77 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL14061758 | 0.69 | LRRK2 (0.45) | LRRK2AAK1GSK3BCHEK1MKNK1 | |
| SCHEMBL14059965 | 0.69 | LRRK2 (0.71) | LRRK2 | |
| SCHEMBL14059204 | 0.69 | LRRK2 (0.46) | LRRK2GSK3BGSK3APRKACACDK8 | |
| SCHEMBL14059734 | 0.69 | LRRK2 (0.63) | LRRK2AAK1 | |
| SCHEMBL14059310 | 0.67 | LRRK2 (0.44) | LRRK2GSK3BGSK3APRKACACDK8 | |
| SCHEMBL14059203 | 0.67 | AAK1 (0.39) | LRRK2AAK1GSK3BCHEK1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |