Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28000336 | 1.00 | DNM1 (0.44) | DNM1MEN1KMT2AEPHX2TP53 | |
| Bromide SCHEMBL28000346 | 0.98 | DNM1 (0.43) | DNM1MEN1KMT2AEPHX2TP53 | |
| Bromide SCHEMBL28000347 | 0.98 | DNM1 (0.43) | DNM1MEN1KMT2AEPHX2TP53 | |
| SCHEMBL1627642 | 0.98 | DNM1 (0.46) | DNM1MEN1KMT2AEPHX2TP53 | |
| SCHEMBL196257 | 0.98 | DNM1 (0.46) | DNM1MEN1KMT2AEPHX2TP53 | |
| SCHEMBL5395332 | 0.98 | DNM1 (0.46) | DNM1MEN1KMT2AEPHX2TP53 | |
| SCHEMBL5391343 | 0.98 | DNM1 (0.46) | DNM1MEN1KMT2AEPHX2TP53 | |
| SCHEMBL5389221 | 0.98 | DNM1 (0.46) | DNM1MEN1KMT2AEPHX2TP53 | |
| SCHEMBL5380729 | 0.98 | DNM1 (0.46) | DNM1MEN1KMT2AEPHX2TP53 | |
| SCHEMBL5402063 | 0.98 | DNM1 (0.46) | DNM1MEN1KMT2AEPHX2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103773324-B | Improve organoclay method of plastic rate in oil base drilling fluid mud | 中国石油化工股份有限公司 | 2016-08-24 | — | — | CN | disclosed |