Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.62 |
| ▸ | ELANE | P08246 | 11/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11749311 | 0.84 | ELANE (0.49) | PDGFRACDK5TYRO3ELANEPOLB | |
| SCHEMBL30881847 | 0.82 | PDGFRA (0.43) | PDGFRACDK5TYRO3ELANEPOLB | |
| SCHEMBL11754694 | 0.81 | ELANE (0.48) | PDGFRACDK5TYRO3ELANEF2 | |
| SCHEMBL726679 | 0.80 | ELANE (0.60) | ELANEPOLBIKBKBF2PLAU | |
| SCHEMBL6113809 | 0.79 | ELANE (0.69) | ELANEPOLBF2PLAU | |
| SCHEMBL517483 | 0.79 | ELANE (0.55) | ELANETSHRF2PLAUL3MBTL1 | |
| SCHEMBL27971365 | 0.79 | ELANE (0.54) | PDGFRACDK5TYRO3ELANEPOLB | |
| SCHEMBL5583818 | 0.79 | ELANE (0.54) | PDGFRACDK5TYRO3ELANEPOLB | |
| SCHEMBL5822952 | 0.78 | MAP2K4 (0.47) | PDGFRACDK5TYRO3ELANEF2 | |
| SCHEMBL8304178 | 0.75 | ELANE (0.54) | PDGFRACDK5TYRO3ELANEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753841-A | N-indazole substituted thiourea derivatives and preparation method and application thereof | 西安交通大学 | 2016-07-13 | — | — | CN | disclosed |