Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 9/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.55 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14362208 | 0.84 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2CCD274 | |
| SCHEMBL29521679 | 0.75 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL330080 | 0.75 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL3285222 | 0.74 | PNMT (0.58) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL671916 | 0.74 | CA1 (0.50) | — | |
| Hydrochloric Acid SCHEMBL4517857 | 0.74 | PNMT (0.58) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29941551 | 0.71 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1487047 | 0.71 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL1038022 | 0.70 | PNMT (0.97) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL7207915 | 0.69 | PNMT (0.50) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105764510-A | An H3 receptor antagonist combined with a cholinesterase inhibitor for use in the treatment of alzheimer's disease | 赛诺菲 | 2016-07-13 | — | — | CN | disclosed |