Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2425390 | 0.84 | HSD11B1 (0.49) | HSD11B1DRD2DRD4DRD3 | |
| SCHEMBL2425376 | 0.82 | HSD11B1 (0.58) | HSD11B1PKLRTACR1CCR1CYP2D6 | |
| SCHEMBL16554013 | 0.81 | TACR1 (0.48) | HSD11B1TACR1USP2 | |
| SCHEMBL21078011 | 0.81 | JAK2 (0.34) | HSD11B1JAK2JAK1CCR1DRD2 | |
| SCHEMBL3585852 | 0.81 | HSD11B1 (0.45) | HSD11B1PKLRTACR1CCR1 | |
| SCHEMBL16565155 | 0.81 | JAK2 (0.41) | HSD11B1JAK2JAK1TACR1CCR1 | |
| SCHEMBL28123227 | 0.80 | TACR1 (0.44) | HSD11B1TACR1 | |
| SCHEMBL16554014 | 0.78 | JAK2 (0.33) | HSD11B1JAK2JAK1 | |
| SCHEMBL3589814 | 0.78 | HSD11B1 (0.45) | HSD11B1PKLRTACR1CYP3A4CYP2D6 | |
| SCHEMBL28077736 | 0.77 | HSD11B1 (0.43) | HSD11B1JAK2JAK1PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745209-A | Triazolopyridine compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2016-07-06 | — | — | CN | disclosed |