Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.69 |
| ▸ | CXCR4 | P61073 | 10/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | CCR2 | P41597 | 1/20 | 0.67 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL593869 | 0.98 | SIGMAR1 (0.71) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL30239538 | 0.98 | SIGMAR1 (0.71) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL6645506 | 0.97 | SIGMAR1 (0.69) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL10897828 | 0.92 | CXCR4 (0.76) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL1259387 | 0.85 | CXCR4 (0.81) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL18754041 | 0.85 | CXCR4 (0.56) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL15043631 | 0.83 | CXCR4 (0.92) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL32889370 | 0.83 | SIGMAR1 (0.54) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL17696101 | 0.83 | SIGMAR1 (0.54) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| Bromide SCHEMBL1257550 | 0.83 | CXCR4 (0.78) | SIGMAR1CXCR4MEN1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104046246-B | The chemical-mechanical planarization of tungsten-containing substrate | 气体产品与化学公司 | 2016-06-15 | — | — | CN | disclosed |