Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.71 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.51 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.51 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.47 |
| ▸ | ARG2 | P78540 | 4/20 | 0.46 |
| ▸ | ARG1 | P05089 | 3/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 4/20 | 0.45 |
| ▸ | NOS2 | P35228 | 3/20 | 0.45 |
| ▸ | NOS3 | P29474 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL17364355 | 1.00 | GSR (0.71) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL9015063 | 0.96 | GSR (0.71) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL9015068 | 0.96 | GSR (0.71) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL1484680 | 0.94 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL7909339 | 0.94 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL1484683 | 0.94 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL5287158 | 0.92 | GSR (0.61) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL5287155 | 0.92 | GSR (0.61) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL26634433 | 0.91 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL2098773 | 0.91 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105316270-B | Engineering bacterium for catalytically producing 1, 5-pentanediamine and application thereof | 宁夏伊品生物科技股份有限公司 | 2019-01-29 | — | — | CN | claimed |
| CN-106414713-B | Whole-cell catalytic produces colibacillus engineering and the application of 1,5- pentanediamine | 宁夏伊品生物科技股份有限公司 | 2019-08-06 | — | — | CN | disclosed |
| CN-105316270-B | Engineering bacterium for catalytically producing 1, 5-pentanediamine and application thereof | 宁夏伊品生物科技股份有限公司 | 2019-01-29 | — | — | CN | disclosed |
| CN-107001236-A | The purification process and 1,5 pentanediamines of a kind of 1,5 pentanediamine | 上海凯赛生物技术研发中心有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-105861586-A | Method for producing pentamethylene diamine by using carbon dioxide desorption process through fermentation | 宁夏伊品生物科技股份有限公司 | 2016-08-17 | — | — | CN | disclosed |