Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.80 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.56 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.56 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.56 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.56 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.56 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.56 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.55 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.55 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.55 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.55 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.51 |
| ▸ | ARG2 | P78540 | 4/20 | 0.50 |
| ▸ | ARG1 | P05089 | 3/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 4/20 | 0.49 |
| ▸ | NOS2 | P35228 | 3/20 | 0.49 |
| ▸ | NOS3 | P29474 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL1484680 | 1.00 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL1484683 | 1.00 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL27204234 | 0.96 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL26634433 | 0.96 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL28088035 | 0.96 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL2098773 | 0.96 | GSR (0.80) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL17364355 | 0.94 | GSR (0.71) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL28078435 | 0.94 | GSR (0.71) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Lysine SCHEMBL9404153 | 0.94 | GSR (0.77) | GSRSLC1A2SLC1A1SLC1A3GNAI3 | |
| Dodecylamine SCHEMBL9441764 | 0.94 | GSR (0.77) | GSRSLC1A2SLC1A1SLC1A3GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024018051-A1 | STABLE PLASMIN COMPOSITIONS FOR ORGAN PRESERVATION AND RECONDITIONING | GRIFOLS WORLDWIDE OPERATIONS LIMITED (IE) | 2024-01-25 | — | — | WO | disclosed |
| EP-2538956-A1 | METHODS AND COMPOSITIONS TO TREAT HEMORRHAGIC CONDITIONS OF THE BRAIN | Edge Therapeutics Inc. (US) | 2013-01-02 | — | — | EP | disclosed |
| US-6214786-B1 | MIXTURE OF SURFACTANTS AND POLYMERS FOR DETERGENTS | THE PROCTER & GAMBLE COMPANY | 2001-04-10 | — | — | US | disclosed |