Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806506 | 0.88 | PDE3B (0.51) | PDE3BPDE3AMAPTSMN1; SMN2MAPKAPK2 | |
| SCHEMBL10473610 | 0.75 | PDE3B (0.69) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL11162096 | 0.72 | PDE3B (0.81) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL11165831 | 0.72 | PDE3B (0.61) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL10412271 | 0.72 | PDE3B (0.61) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL10473876 | 0.70 | PDE3B (0.67) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL21944903 | 0.70 | EGFR (0.46) | MAPTSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL10472699 | 0.70 | PDE3B (0.64) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL10412281 | 0.70 | PDE3B (0.55) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL3723997 | 0.69 | PDE3B (1.00) | PDE3BPDE3AMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557824-B2 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2013-10-15 | — | — | US | claimed |
| US-20100240676-A1 | THIAZOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-09-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240676-A1 | THIAZOLE DERIVATIVES | CCNE2, PKD1, PKD2 | PDE3B 3009/4885PDE3A 3204/4885MAPT 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.