Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.46 |
| ▸ | KIT | P10721 | 8/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | CDK11B | P21127 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28222510 | 0.83 | RET (0.52) | RETKDRMKNK2MKNK1KIT | |
| SCHEMBL28119359 | 0.80 | NR1H2 (0.55) | KITABL1BRAFDDR1CSF1R | |
| SCHEMBL28079302 | 0.79 | KIT (0.54) | RETKDRMKNK2MKNK1KIT | |
| SCHEMBL27910162 | 0.75 | NR1H2 (0.57) | RETKITBRAFCSF1R | |
| SCHEMBL28027723 | 0.73 | MKNK2 (0.46) | RETKDRMKNK2MKNK1KIT | |
| SCHEMBL28027123 | 0.73 | KMT2A (0.55) | RETKDRMKNK2MKNK1KIT | |
| SCHEMBL2313005 | 0.71 | RET (0.51) | RETKDRMKNK2MKNK1KIT | |
| SCHEMBL27928422 | 0.71 | PDE3B (0.52) | KITABL1CSF1RBCRCYP3A4 | |
| SCHEMBL3311056 | 0.70 | NR1H2 (0.52) | RETKDRMKNK2MKNK1KIT | |
| Hydrochloric Acid SCHEMBL393146 | 0.70 | RET (0.50) | RETKDRMKNK2MKNK1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103420977-B | There is the acetylene-derivative of anti-tumor activity | 上海医药集团股份有限公司 | 2016-06-22 | — | — | CN | disclosed |