Methylene Chloride

Methylene Chloride

SCHEMBL28079443

ClCCl.O=C(Cl)CCCCl

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
TP53 P04637 1/20 0.52
TSHR P16473 4/20 0.48
TDP1 Q9NUW8 1/20 0.35
FAAH O00519 1/20 0.31
BBOX1 O75936 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL72850 0.97
SCHEMBL27802390 0.94
Hydrochloric Acid SCHEMBL27583419 0.91 ALDH1A1 (0.50) ALDH1A1TP53TSHRTDP1FAAH
Aluminum Chloride Anhydrous SCHEMBL27583418 0.88 ALDH1A1 (0.48) ALDH1A1TP53TSHRTDP1
SCHEMBL77065 0.88
Formic Acid SCHEMBL28264955 0.86 ALDH1A1 (0.46) ALDH1A1TP53TSHRTDP1
Hypophosphorous Acid SCHEMBL11664036 0.86 ALDH1A1 (0.46) ALDH1A1TP53TSHRTDP1
SCHEMBL24243989 0.85 TSHR (0.59) ALDH1A1TP53TSHRTDP1FAAH
SCHEMBL8624800 0.85 TSHR (0.59) ALDH1A1TP53TSHRTDP1FAAH
SCHEMBL4970742 0.85 TSHR (0.59) ALDH1A1TP53TSHRTDP1FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118125969-A Haloperidol with excellent biological performance and preparation method and application thereof 湖南洞庭药业股份有限公司 2024-06-04 CN claimed
CN-106380441-B Synthetic method of fexofenadine intermediate 上海雅本化学有限公司 2020-08-14 CN claimed
CN-118125969-A Haloperidol with excellent biological performance and preparation method and application thereof 湖南洞庭药业股份有限公司 2024-06-04 CN disclosed
CN-113548994-A Preparation method of (S) -3- (2, 2, 2-trifluoroethyl) -pyrrolidine hydrochloride 西安都创医药科技有限公司 2021-10-26 CN disclosed
CN-106795100-B Compound, pharmaceutical composition and its purposes in treatment neurodegenerative disease 里尔大学 2019-11-19 CN disclosed
CN-110049979-A BROMODOMAIN INHIBITORS 艾伯维公司 2019-07-23 CN disclosed
CN-107709316-A The benzodioxan derivative of 2 (base of 1 heteroaryl piperazine 4) methyl 1,4 as α 2C antagonists 奥赖恩公司 2018-02-16 CN disclosed
CN-106795100-A Compound, pharmaceutical composition and its purposes in nerve degenerative diseases are treated 法国里尔第二大学 2017-05-31 CN disclosed
CN-104098771-B A kind of preparation method of the dissaving polymer with oxidoreduction response 西北工业大学 2016-08-24 CN disclosed