Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | CASP1 | P29466 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688670 | 0.78 | ALDH1A1 (0.42) | ALDH1A1CASP1TSHRCYP3A4KDM4E | |
| SCHEMBL29642345 | 0.78 | ALDH1A1 (0.42) | ALDH1A1CASP1TSHRCYP3A4KDM4E | |
| SCHEMBL31184930 | 0.77 | ALDH1A1 (0.57) | ALDH1A1CASP1TSHRCYP3A4PDE10A | |
| SCHEMBL17653959 | 0.77 | ALDH1A1 (0.52) | ALDH1A1CASP1TSHRCYP3A4PDE10A | |
| SCHEMBL61459 | 0.77 | ALDH1A1 (0.57) | ALDH1A1CASP1TSHRCYP3A4PDE10A | |
| SCHEMBL18992027 | 0.77 | ALDH1A1 (0.52) | ALDH1A1CASP1TSHRCYP3A4PDE10A | |
| SCHEMBL2808490 | 0.77 | ALDH1A1 (0.52) | ALDH1A1CASP1TSHRCYP3A4PDE10A | |
| SCHEMBL9815925 | 0.76 | TSHR (0.38) | ALDH1A1CASP1TSHRCYP3A4PLA2G7 | |
| SCHEMBL16178467 | 0.76 | PTPN1 (0.42) | ALDH1A1CASP1TSHRCYP3A4KDM4E | |
| SCHEMBL3220960 | 0.76 | TDP1 (0.42) | ALDH1A1CYP3A4KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118259012-A | Method for global analysis of functional histidines in proteins | 深圳湾实验室 | 2024-06-28 | — | — | CN | claimed |
| CN-118259012-A | Method for global analysis of functional histidines in proteins | 深圳湾实验室 | 2024-06-28 | — | — | CN | disclosed |
| EP-3246327-B1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SI CHUAN UNIV (CN) | 2022-11-23 | — | — | EP | disclosed |
| EP-3628103-A1 | NONAQUEOUS ELECTROLYTE, NONAQUEOUS ELECTROLYTE ENERGY STORAGE DEVICE, AND METHOD FOR PRODUCING NONAQUEOUS ELECTROLYTE ENERGY STORAGE DEVICE | Robert Bosch GmbH (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | St. Chuan University (CN) | 2019-04-23 | — | — | US | disclosed |
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | St. Chuan University (CN) | 2019-04-23 | — | — | US | disclosed |
| CN-106800654-B | A method of polybenzoxazoles is prepared based on backbone chain type benzoxazine | 江苏大学 | 2019-02-05 | — | — | CN | disclosed |
| CN-105837575-B | 3- acetenyl Pyrazolopyrimidine derivative and its preparation method and application | 四川大学 | 2019-01-15 | — | — | CN | disclosed |
| WO-2018224286-A1 | NONAQUEOUS ELECTROLYTE, NONAQUEOUS ELECTROLYTE ENERGY STORAGE DEVICE, AND METHOD FOR PRODUCING NONAQUEOUS ELECTROLYTE ENERGY STORAGE DEVICE | Lithium Energy and Power GmbH & Co. KG (DE) | 2018-12-13 | — | — | WO | disclosed |
| EP-3246327-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | Si Chuan University (CN) | 2017-11-22 | — | — | EP | disclosed |
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2010-02-25 | — | — | US | disclosed |
| US-20080194552-A1 | Aminopyrimidine Derivatives With Tie2 Inhibiting Activity | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194552-A1 | Aminopyrimidine Derivatives With Tie2 Inhibiting Activity | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194552-A1 | Aminopyrimidine Derivatives With Tie2 Inhibiting Activity | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | US | disclosed |
| CN-101198602-A | Saminopyrimidine derivates with tIE2 inhibiting activity | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | CN | disclosed |
| EP-1893605-A2 | SAMINOPYRIMIDINE DERIVATES WITH TIE2 INHIBITING ACTIVITY | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| CN-101137652-A | Pyrimidine compounds having tie2 (tek) inhibitory activity | ASTRAZENECA AB (SE) | 2008-03-05 | — | — | CN | disclosed |
| EP-1863805-A1 | PYRIMIDINE COMPOUNDS HAVING TIE2 (TEK) INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103449-A2 | SAMINOPYRIMIDINE DERIVATES WITH TIE2 INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2006-10-05 | — | — | WO | disclosed |
| WO-2006082373-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2006-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | DPYD, TYMP, WEE1 | ALDH1A1 78/4885CASP1 1181/4885TSHR 4320/4885 |
| US-20080194552-A1 | Aminopyrimidine Derivatives With Tie2 Inhibiting Activity | TIE1, TEK, FLT1 | ALDH1A1 1756/4885CASP1 3497/4885TSHR 3638/4885 |
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | TEK, TYMP, TIE1 | ALDH1A1 2198/4885CASP1 3734/4885TSHR 2425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.