Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.71 |
| ▸ | RAB9A | P51151 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 7/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.71 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.71 |
| ▸ | RELA | Q04206 | 3/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL803150 | 0.88 | RAB9A (0.69) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL10582882 | 0.86 | SMN1; SMN2 (0.82) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL10561342 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL9805438 | 0.83 | RAB9A (0.63) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL12684741 | 0.83 | RAB9A (0.63) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL12002675 | 0.81 | NPC1 (0.61) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL4943133 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL17954213 | 0.81 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL152870 | 0.81 | NPC1 (0.66) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL12603839 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104326952-B | Prepare method and its intermediate of pyridazinone compound | 住友化学株式会社 | 2016-08-24 | — | — | CN | disclosed |